I’m lucky because life is easier on my Mac, as I read the tales from Windows users 
If I just want to capture a video+sound of a patch I record in Quicktime Player, routing the audio to it with Soundflower, and that’s it. The resulting .mov works beautifully in max quality on YT. Sometimes I just make a YT video from a screenshot/picture and the recorded .wav from VCV Recorder. In that case I use ffmpeg via my script to make the finished video, which is quite small. If I were to make an edited video I would record the .wav with Recorder and the video with Quicktime, edit the video part in iMovie and then glue the two together with an ffmpeg script. The recommended encoder settings for YT can be found here.