I’m using OSC for sending CV like midi and envelopes, and an 8-channel virtual audio cable to send audio which is then processed in TD for audio reactivity
It depends entirely on the complexity of the patches. I am using an hp omen 15 with 9th gen i7, 16gb ram and RTX2060 and it does a good job.
With touchdesigner, I usually make sure it runs at 60fps, then force the framerate to 30fps to halve the load and ensure there is resources left for rack (and streaming).