Are we talking about Intel architecture plugins running through host module on an Apple Silicon machine? To be honest I don’t even know whether the host module is able to do that, but if it does it transparently via the plugin running in Rosetta2, then yeah, the rosetta emulation might hit those GUI’s, don’t know. At any rate you should obviously prefer ARM64 plugins when possible so it’s the same architecture.
I would expect it to run as well as my original M1 Air test, or actually better, since the orgiginal test was Rack under Rosetta2: Apple Silicon M1 - system-on-a-chip to Rule Them All. - #117 by LarsBjerregaard